Every year, unfavorable environmental factors significantly affect crop productivity and threaten food security. Plants are sessile; they cannot move to escape unfavorable environmental conditions, and therefore, they activate a variety of defense pathways. Among them are processes regulated by stress‐associated proteins (SAPs). SAPs have a specific zinc finger domain (A20) at the N‐terminus and either AN1 or C2H2 at the C‐terminus. SAP proteins are involved in many biological processes and in response to various abiotic or biotic constraints. Most SAPs play (...) a role in conferring transgenic stress resistance and are stress‐inducible. The emerging field of SAPs in abiotic or biotic stress response regulation has attracted the attention of researchers. Although SAPs interact with various proteins to perform their functions, the exact mechanisms of these interactions remain incompletely understood. This review aims to provide a comprehensive understanding of SAPs, covering their diversity, structure, expression, and subcellular localization. SAPs play a pivotal role in enabling crosstalk between abiotic and biotic stress signaling pathways, making them essential for developing stress‐tolerant crops without yield penalties. Collectively, understanding the complex regulation of SAPs in stress responses can contribute to enhancing tolerance against various environmental stresses through several techniques such as transgenesis, classical breeding, or gene editing. (shrink)

This book presents an original comprehensive approach to some of the most difficult problems concerning sense-perception and other mental states. After rejecting prevailing approaches, the author presents his own viewpoint which may be characterized as direct, critical realism. Basing his conclusions on conceptual analysis, psychological evidence and historical considerations, the author is able to offer new insights into traditionally unsolved problems concerning the nature of perceptual states, the ontological status of perceptual environment, the cognitive mechanism in perception and the explanation (...) of perceptual mistakes. The book also discusses the implications of this approach for other mental states such as memory and consciousness. (shrink)

Well-Being and Death addresses philosophical questions about death and the good life: what makes a life go well? Is death bad for the one who dies? How is this possible if we go out of existence when we die? Is it worse to die as an infant or as a young adult? Is it bad for animals and fetuses to die? Can the dead be harmed? Is there any way to make death less bad for us? Ben Bradley defends the (...) following views: pleasure, rather than achievement or the satisfaction of desire, is what makes life go well; death is generally bad for its victim, in virtue of depriving the victim of more of a good life; death is bad for its victim at times after death, in particular at all those times at which the victim would have been living well; death is worse the earlier it occurs, and hence it is worse to die as an infant than as an adult; death is usually bad for animals and fetuses, in just the same way it is bad for adult humans; things that happen after someone has died cannot harm that person; the only sensible way to make death less bad is to live so long that no more good life is possible. (shrink)

Is or has economics ever been the imperial social science? Could or should it ever be so? These are the central concerns of this book. It involves a critical reflection on the process of how economics became the way it is, in terms of a narrow and intolerant orthodoxy, that has, nonetheless, increasingly directed its attention to appropriating the subject matter of other social sciences through the process termed "economics imperialism". In other words, the book addresses the shifting boundaries between (...) economics and the other social sciences as seen from the confines of the dismal science, with some reflection on the responses to the economic imperialists by other disciplines. Significantly, an old economics imperialism is identified of the "as if market" style most closely associated with Gary Becker, the public choice theory of Buchanan and Tullock and cliometrics. But this has given way to a more "revolutionary" form of economics imperialism associated with the information-theoretic economics of Akerlof and Stiglitz, and the new institutional economics of Coase, Wiliamson and North. Embracing one "new" field after another, economics imperialism reaches its most extreme version in the form of "freakonomics", the economic theory of everything on the basis of the most shallow principles. By way of contrast and as a guiding critical thread, a thorough review is offered of the appropriate principles underpinning political economy and its relationship to social science, and how these have been and continue to be deployed. The case is made for political economy with an interdisciplinary character, able to bridge the gap between economics and other social sciences, and draw upon and interrogate the nature of contemporary capitalism. (shrink)

Many political realists endorse some notion of political normativity. They think that there are certain normative claims about politics that do not depend on moral premises. The most prominent moralist objections to political normativity have been metaethical: specifically, that political normativity is not genuinely normative; and that it is incapable of justifying normative claims. In this article, I criticize the latter metaethical objection. I argue that the objection presupposes a notion of ‘justification’ that renders it something that is no longer (...) necessarily valuable to realists. I then extend this argument to show that all metaethical objections to political normativity are unsuccessful. Furthermore, insofar as these metaethical objections purport to constrain the types of politics that realists endorse, realists should regard them as another expression of what Raymond Geuss calls ‘dead politics’. (shrink)

Given the plethora of competing logical theories of validity available, it’s understandable that there has been a marked increase in interest in logical epistemology within the literature. If we are to choose between these logical theories, we require a good understanding of the suitable criteria we ought to judge according to. However, so far there’s been a lack of appreciation of how logical practice could support an epistemology of logic. This paper aims to correct that error, by arguing for a (...) practice-based approach to logical epistemology. By looking at the types of evidence logicians actually appeal to in attempting to support their theories, we can provide a more detailed and realistic picture of logical epistemology. To demonstrate the fruitfulness of a practice-based approach, we look to a particular case of logical argumentation—the dialetheist’s arguments based upon the self-referential paradoxes—and show that the evidence appealed to support a particular theory of logical epistemology, logical abductivism. (shrink)

Background Voluntary assisted dying became lawful in Victoria, the first Australian state to permit this practice, in 2019 via the Voluntary Assisted Dying Act 2017 (Vic). While conscientious objection by individual health professionals is protected by the Victorian legislation, objections by institutions are governed by policy. No research has been conducted in Victoria, and very little research conducted internationally, on how institutional objection is experienced by patients seeking assisted dying. Methods 28 semi-structured interviews were conducted with 32 family caregivers and (...) one patient about the experience of 28 patients who sought assisted dying. Participants were interviewed during August-November 2021. Data from the 17 interviews (all with family caregivers) which reported institutional objection were analysed thematically. Results Participants reported institutional objection affecting eligibility assessments, medication access, and taking the medication or having it administered. Institutional objection occurred across health settings and was sometimes communicated obliquely. These objections resulted in delays, transfers, and choices between progressing an assisted dying application and receiving palliative or other care. Participants also reported objections causing adverse emotional experiences and distrust of objecting institutions. Six mediating influences on institutional objections were identified: staff views within objecting institutions; support of external medical practitioners and pharmacists providing assisted dying services; nature of a patient’s illness; progression or state of a patient’s illness; patient’s geographical location; and the capability and assertiveness of a patient and/or caregiver. Conclusions Institutional objection to assisted dying is much-debated yet empirically understudied. This research found that in Victoria, objections were regularly reported by participants and adversely affected access to assisted dying and the wider end-of-life experience for patients and caregivers. This barrier arises in an assisted dying system that is already procedurally challenging, particularly given the limited window patients have to apply. Better regulation may be needed as Victoria’s existing policy approach appears to preference institutional positions over patient’s choice given existing power dynamics. (shrink)

In this article, James Gibson’s influential notion of “perceptual affordances” is applied to the romantic realm. The core idea of Gibson’s view rests on the possible, meaningful actions that the perceptual environment offers the animal. In order to sustain this idea, Gibson posits two additional major characteristics of affordances: (a) affordances are perceived in a direct cognitive manner, and (b) affordances have a unique ontological status that is neither subjective nor objective. While I accept the core idea, I have doubts (...) as to whether the two other characteristics are necessary in other types of affordances, such as social and romantic affordances. The romantic realm offers an abundance of many enticing affordances. In this regard, I discuss phenomena like the availability of a romantic alternative, romantic ambivalence, choosing a romantic partner, sexual fantasies, the road not taken, reciprocity, playing hard to get, cultivating backup mates, romantic affordances in old age and in the digital realm. In light of the abundance and complexity of romantic affordances in our current romantic environment, knowing the nature of these affordances is most useful from both pragmatic and theoretical viewpoints. (shrink)

Sufficientarians face a problem of arbitrariness: why place a sufficiency threshold at any particular point? One response is to seek universal goods to justify a threshold. However, this faces difficulties (despite sincere efforts) by either being too low, or failing to accommodate individuals with significant cognitive disabilities. Some sufficientarians have appealed to individuals’ subjective evaluations of their lives. I build on this idea, considering another individualized threshold: ‘tolerability’. I respond to some traditional challenges to individualistic approaches to justice: ‘expensive’ tastes, (...) and adaptive preferences. Finally, I end by offering some suggestions about how this relates to policymaking. (shrink)

Harry Brighouse and Adam Swift argue that education is a positional good; this, they hold, implies that there is a qualified case for leveling down educational provision. In this essay, Ben Kotzee discusses Brighouse and Swift's argument for leveling down. He holds that the argument fails in its own terms and that, in presenting the problem of educational justice as one of balancing education's positional and nonpositional benefits, Brighouse and Swift lose sight of what a consideration of the nonpositional benefits (...) by itself can reveal. Instead of focusing on education's positional benefits, Kotzee investigates what emphasizing education's nonpositional benefits would imply for educational justice. Drawing on recent work in social epistemology, Kotzee holds that theories of educational justice would benefit from a consideration of the virtue of epistemic justice, and he outlines solutions to a number of problems in the area from this perspective. (shrink)

Existing regulation of end-of-life care is flawed. Problems include poorly-designed laws, policies, ethical codes, training, and funding programs, which often are neither effective nor helpful in guiding decision-making. This leads to adverse outcomes for patients, families, health professionals, and the health system as a whole. A key factor contributing to the harms of current regulation is a siloed approach to regulating end-of-life care. Existing approaches to regulation, and research into how that regulation could be improved, have tended to focus on (...) a single regulatory instrument (e.g., just law or just ethical codes). As a result, there has been a failure to capture holistically the various forces that guide end-of-life care. This article proposes a response to address this, identifying “regulatory space” theory as a candidate to provide the much-needed holistic insight into improving regulation of end-of-life care. The article concludes with practical implications of this approach for regulators and researchers. (shrink)

We develop the general theory of topometric spaces, i.e., topological spaces equipped with a well-behaved lower semi-continuous metric. Spaces of global and local types in continuous logic are the motivating examples for the study of such spaces. In particular, we develop Cantor-Bendixson analysis of topometric spaces, which can serve as a basis for the study of local stability (extending the ad hoc development in Ben Yaacov I and Usvyatsov A, Continuous first order logic and local stability. Trans Am Math Soc, (...) in press), as well as of global ${\aleph_0}$ -stability. We conclude with a study of perturbation systems (see Ben Yaacov I, On perturbations of continuous structures, submitted) in the formalism of topometric spaces. In particular, we show how the abstract development applies to ${\aleph_0}$ -stability up to perturbation. (shrink)

This volume addresses the relationship between law and neoliberalism. Assembling work from established and emerging legal scholars, political theorists, philosophers, historians and sociologists from around the world, including the Americas, Australia, Europe and the United Kingdom, it addresses the conceptual, legal, and political relationships between liberal legality and neoliberal economics. More specifically, the book analyses the role that legality plays in the dominant economic force of our time: offering both a legal corrective to scholarship in economics and political economy that (...) has paid insufficient attention to legal ideas and, at the same time, a political economic corrective to legal scholarship which has only recently turned to theorizing neoliberalism. It will be of enormous interest to those working at the intersection of law and politics in our neoliberal age. (shrink)

Ethical arguments about assisted dying often focus on whether or not respect for an individual’s autonomy gives a reason to offer them an assisted death if they want it. In this paper, I present an argument for legalising assisted dying which appeals to the autonomy of people who don’t want to die. Adding that option can transform the nature of someone’s choice set, enabling them to pursue other options voluntarily where that would otherwise be harder or impossible. This does not (...) contradict the more familiar arguments for legalising assisted dying based on the autonomy of those who seek to die. But it does suggest that a wider constituency of support for that legislative change might be created by emphasising that one need not be in that position to be benefited by the change. (shrink)

The paper is dealing with the foundation of the Division for German Literature and Language at the Hebrew University of Jerusalem from the point of view of its first head, Prof. Stéphane Mosès.

According to the principle Grice calls 'Modified Occam's Razor' (MOR), 'Senses are not to be multiplied beyond necessity'. More carefully, MOR says that if there are distinct ways in which an expression is regularly used, then, all other things being equal, we should favour the view that the expression is unambiguous and that certain uses of it can be explained in pragmatic terms. In this paper I argue that MOR cannot have the central role that is typically assigned to it (...) by those who deploy it. More specifically, I argue that potential justifications of the epistemic import of parsimony in semantic theorizing are problematic, and that even if MOR could be justified, it has a redundant role to play in adjudicating the debate between the ambiguity-theorist and the proponent of the pragmatic approach. (shrink)

Throughout his work on the rationality of epistemic dependence, John Hardwig makes the striking observation that he believes many things for which he possesses no evidence (1985, 335; 1991, 693; 1994, 83). While he could imagine collecting for himself the relevant evidence for some of his beliefs, the vastness of the world and constraints of time and individual intellect thwart his ability to gather for himself the evidence for all his beliefs. So for many things he believes what others tell (...) him, as we all do. Epistemic dependence is the responsible choice, he argues, because he can be reasonably sure that those on whom he depends know more about the subject than he does. Epistemic dependence on experts is a smarter bet than epistemic autonomy: after all, Hardwig reasons, “if I were to pursue epistemic autonomy across the board, I would succeed in holding relatively uninformed, unreliable, crude, untested, and therefore irrational beliefs” (1985, 340) [...] In this paper I argue against what I call Hardwig’s no-evidence thesis: that knowledge and belief based on testimony are knowledge and belief for which the knower possesses no evidence. Against the no-evidence thesis, I propose we recognize that layperson B’s good reason to believe that expert A has good reason to believe proposition p constitutes evidence for B for p. I argue that the reasons Hardwig gives for the no-evidence thesis are inconclusive at best; at worst the no-evidence thesis coupled with his recognition of expert interdependence exposes him to recent criticisms by Stella Gaon and Stephen Norris. By rejecting the no-evidence thesis, we can recognize with Hardwig the importance of expert epistemic interdependence while avoiding the paradoxical implications of his position. (shrink)

John Stuart Mill's harm principle holds that an individual's freedom can only be restricted to prevent harm to others. However, there is an important ambiguity between a strong version, which limits legitimate interference to self-defense and therefore prohibits society from protecting third parties (those who are not its members), and a narrow version, which grants any society universal jurisdiction to prevent nonconsensual harms, no matter who is harmed. Mill sometimes appeals to the strong harm principle to preclude interference, but elsewhere (...) endorses measures (including humanitarian foreign intervention and animal cruelty laws) to protect third parties, suggesting that he subscribes only to the weak harm principle. This ambiguity regarding who it is that society has standing to protect has important implications for the scope of individual freedom. (shrink)

The 'Art of Life' is John Stuart Mill's name for his account of practical reason. In this volume, eleven leading scholars elucidate this fundamental, but widely neglected, element of Mill's thought. Mill divides the Art of Life into three 'departments': 'Morality, Prudence or Policy, and Æsthetics'. In the volume's first section, Rex Martin, David Weinstein, Ben Eggleston, and Dale E. Miller investigate the relation between the departments of morality and prudence. Their papers ask whether Mill is a rule utilitarian and, (...) if so, whether his practical philosophy must be incoherent. The second section contains papers by Jonathan Riley and Wendy Donner, who explore the relation between the departments of morality and aesthetics. They discuss issues ranging from supererogation to aesthetic pleasure and humanity's relationship with nature. -/- The papers in the third section consider the Art of Life's axiological first principle, the principle of utility. Elijah Millgram contends that Mill's own life refutes his claim that the Art of Life has a single axiological first principle. Philip Kitcher maintains that Mill has a dynamic axiology requiring us to continually refine our conception of the good. In the final section, three papers address what it means to put the Art of Life into practice. Robert Haraldsson locates an 'Art of Ethics' in On Liberty that is in tension with the Art of Life. Nadia Urbinati plumbs the classical roots of Mill's view of the good life. Finally, Colin Heydt develops Mill's suggestion that we regard our own lives as works of art. (shrink)

Most crises of knowledge stem from lack of information. The current crisis of romantic knowledge stems from the opposite reason: too much information. The abundance of romantic information is the main reason for this crisis, making the romantic realm more complex, diverse and flexible than ever. In recent times, there has become a significantly greater emphasis on romantic ignorance. Romantic abundance facilitates finding a romantic (and sexual) partner, but is an obstacle for initiating and maintaining enduring, profound romantic relationships. A (...) major optimal tool for overcoming these difficulties is a combination of intuition and deliberate thinking. The abundance of romantic information does not make adequate knowledge easy to obtain, and conversely has created a far more complex minefield to navigate. Nevertheless, our contemporary society has enabled the most flourishing romantic environment in the history of love. (shrink)

Most countries have adopted a total brain standard for determining death, with some opting instead for a brainstem standard. The total brain standard holds that an individual with “irreversible ces...

We develop the theory of germs of generic functions in simple theories. Starting with an algebraic quadrangle (or other similar hypotheses), we obtain an "almost" generic group chunk, where the product is denned up to a bounded number of possible values. This is the first step towards the proof of the group configuration theorem for simple theories, which is completed in [3].

The ArgumentEinstein's concept of causality as analyzed in this paper is a thick concept comprised of: (a) regularity; (b) locality; (c) symmetry considerations leading to conservation laws; (d) mutuality of causal interaction. The main theses are: 1. Since (b)–(d) are not elements of Hume's concept of causality, Einstein's concept, the concept embedded in the theory of relativity, is manifestly non–Humean. 2. On a Humean conception, Newtonian mechanics is a paradigmatically causal theory. Einstein, however, regarded this theory as causally deficient, for (...) it fails to comply with both (b) and (d). Special relativity was (partly) motivated by the wish to correct the first of these failures; general relativity the second. 3. Ironically, general relativity, based on the thick concept of causality, opens the way for a conventionalist understanding of that concept. 4. With regard to human freedom, Einstein professed to be a Spinozist. However, he suggested a version of soft determinism, not found in Spinoza. (shrink)

In “On the Nature of Logical Judgment” (published 1893) and A New Law of Thought and Its Logical Bearings (published 1911), E. E. Constance Jones developed a view on which we can think and talk about the round-square. On her view, the round-square has a kind of existence; otherwise, sentences about it wouldn’t be meaningful. But it doesn’t exist in space, since it’s both round and square, and nothing in space is both. Although it has a kind of existence in (...) what she calls “a Region of Supposition,” we can truly say that it “doesn’t exist,” if what we mean is that it doesn’t exist in space. It plays a role in reasoning, since we need to be able to reason about it to conclude that it doesn’t exist in space. And, although the round-square is both round and square, the Law of Contradiction needn’t be violated, provided that it’s understood in light of Jones’s distinction between two kinds of negation. (shrink)

In The Solace, Joshua Glasgow’s main claim is that life has “radiant value” and that death inherits some of that value; this provides us with a source of solace. He also argues that death is bad not only in virtue of depriving us of good things, but also in virtue of depriving us of opportunities for good things. I raise difficulties for these claims.

I aim to establish in this article why Aribiah Attoe, like other determinists before him, got it wrong in arguing for the possibility of predeterminism in a materially evolving universe. I will do this by proving two things: I will first establish the inconsistency of the idea of predeterminism in an evolving universe. Then, I argue that the adirectionality presupposed by an evolutionary universe gives room for free will and negates the argument for a predeterministic universe. I aim to achieve (...) the above by exposing why the view which upholds the universe and all existents within it as lacking free will – or the possibility of adirectionality – stems from a category error on the part of the determinists. Lastly, I defend the position that for predeterminism to stand a chance against the free will of animate things-in-the-world, it must deny the possibility of an evolving/expanding universe that is adirectional and suggestive of boundlessness, and the possibility that some events are not fundamentally necessary reactions to previous states of affairs. (shrink)